323
Cell Junctions, Structure,
Function, and Regulation
Susan E. LaFlamme
1
and Peter A. Vincent
2
1
Center for Cell Biology and Cancer Research, Albany Medical College, Albany,
NY, USA
2
Center for Cardiovascular Sciences, Albany Medical College, Albany, NY, USA
1
Cell–matrix Adhesion
326
1.1
Overview
326
1.2
Extracellular Matrix
326
1.2.1
Collagens
327
1.2.2
Laminins
329
1.2.3
Other Extracellular Matrix Proteins
330
1.3
Integrins
331
1.3.1
The Integrin Family
331
1.3.2
Integrin Ligands
332
1.3.3
Integrin Signaling
333
1.3.4
Integrin-associated Proteins
336
1.4
Focal Adhesions
341
1.4.1
Components of Focal Adhesion
341
1.4.2
Regulation of Focal Adhesion Assembly
342
1.5
Hemidesmosomes
343
1.5.1
Assembly of Hemidesmosomes
344
1.5.2
Signaling by
α
6
β
4
345
2
Cell–Cell Junctions
345
2.1
Overview
345
2.2
Cadherin Superfamily
347
2.3
Type I/II Cadherins and Adherens Junctions
349
2.3.1
Extracellular Domain: Cis- and Trans-cadherin Dimerization
350
2.3.2
Cytoplasmic Domain: Lateral Clustering and Cytoskeletal
Attachment
352
2.3.3
Regulation of Cadherin–Catenin Complex
354
2.3.4
Other Components of Adherens Junctions: Nectin and Afadin
356
Encyclopedia of Molecular Cell Biology and Molecular Medicine, 2nd Edition
. Edited by Robert A. Meyers.
Copyright
2004 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
ISBN: 3-527-30544-0
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