221
Cancer Stem Cells
Michael F. Clarke
1
and Andrew T. Hass
2
1
Department of Hematology and Oncology, The University of Michigan,
Ann Arbor, Michigan, USA
2
Cellular and Molecular Biology Program, The University of Michigan,
Ann Arbor, Michigan, USA
1
Introduction
223
2
Evidence for Cancer Stem Cells
223
2.1
Viewing a Tumor as an Abnormal Organ
223
2.2
Recent Evidence for AML and Breast Cancer Stem Cells
224
3
Properties of Normal Stem Cells
226
3.1
The Hematopoietic Stem Cell and its Properties
226
3.2
The Hierarchy of the Hematopoietic System
227
3.3
Self-renewal: The DeFning Property of Stem Cells
227
4
Genetic Regulation of Self-renewal in Normal Stem Cells
and Cancer Cells
228
4.1
Tissue and Tumor Growth: A Balancing Act
228
4.2
Multiple Oncogenes Implicated in Self-renewal
228
4.3
Possibility of a Common Self-renewal Pathway among Multiple
Cell Types
230
5
Target Cells for Malignant Transformation
230
5.1
Stem Cells as Targets for Malignant Transformation
230
5.2
Progenitor Cells as Targets for Malignant Transformation
231
5.3
Targets for Malignant Transformation in Hematopoietic
Malignancies
232
6
Implications of Cancer Stem Cells for the Diagnosis and
Treatment of Cancer
233
6.1
Cancer Stem Cells Would Explain Several Conundrums of
Cancer Biology
233
Encyclopedia of Molecular Cell Biology and Molecular Medicine, 2nd Edition
. Edited by Robert A. Meyers.
Copyright
2004 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
ISBN: 3-527-30544-0
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