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Cancer Chemotherapy, Theoretical Foundations of
Keywords
Cancer
One of the most common human diseases.
Drug Design
The process of developing a new medicine.
Therapy
The administration to human subjects of a drug
p53
A tumour suppressor protein seen to be frequently mutated in cancer cells.
Cell Cycle
The process through which cells grow and divide.
Angiogenesis
The formation of new blood vessels.
Hsp90
A ubiquitously expressed protein that acts to protect cells from thermal stress.
Erb B
The epidermal growth factor receptor.
E2F
A key protein transcription regulating protein involved in cell cycle control.
¥
The massive research efforts that have been applied to understanding the workings
of the cancer cell have provided a wealth of detail on key mechanisms that become
abnormal during tumorigenesis. Translating and exploiting this large body of cancer
research information in the design and implementation of new drugs should yield
better medicines for the cancer patient than those that are currently available.
It is an implicit assumption in this objective that mechanism-based agents that
target discrete abnormalities in tumor cells will provide improved treatments over
conventional therapies. In this respect, we are beginning to witness emerging clinical
efFcacy in a new generation of cancer drugs designed to target key mechanisms in
tumor cells.
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