Calcium Biochemistry
137
ATP
ADP
ECF
Kidney 1,25-(OH)
2
D
3
25-(OH) D
3
P
3
PP
2
PLC
R
ER
M
ECF
Hemonon
Intestine
Calcium homeostasis
+
+
+
+
+
+
+
Bone
CT
ECF
N
PTH
Ca
2
+
Ca
2
+
Ca
2
+
Ca
2
+
Ca
2
+
Ca
2
+
Ca
2
+
Na
+
ACP
ATP
Vit D
Liver
E
3
Fig. 1
Schematic view of the different systems participating in calcium homeostasis. The Fgure integrates the different organs, hormones, and the
cellular systems involved in the regulation of calcium. CT, calcitonin; PTH, parathyroid hormone; EC±, extracellular fluid; ER, endoplasmic reticulum;
M, mitochondrion; N, nucleus; R, receptor; C, channel; E, exchanger; P, pump; G, G protein; PLC, phospholipase C; PIP2,
phosphatidylinositol-4,5-diphosphate; IP3, inositol-1,4,5-triphosphate.
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