Brain Development
123
positive electrode, directed by the electric
feld generated during EP. EP may Fur-
ther be combined with loss-oF-Function
studies, as EP can target any charged
molecules. Indeed, RNAi as well as mor-
pholino oligo-mediated gene attenuation
in a restricted area using EP has already
been reported. Hence, EP will oFFer a rela-
tively high-throughput means oF assaying
or evaluating gene Function and regula-
tion, which will be important in light oF
the flood oF inFormation coming From the
genome projects.
Acknowledgments
I would like to thank Dr. Robb KrumlauF
For valuable suggestions in preparing
the manuscript at the Stowers Institute
For Medical Research, Kansas City, MO,
and an anonymous reviewer For critical
reading oF the manuscript. I also thank the
members oF the KrumlauF lab For helpFul
discussions. Takayoshi Inoue is supported
by the Human ±rontier Science Program
Long-term Fellowship (LT00293/2000-M).
See also
Behavior Genes; Genetics,
Molecular Basis oF.
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