110
Brain Development
pros mRNA/Staufen/Miranda complex
Prospero/Miranda complex
Numb/Pon complex
Neuroblast
Mitosis
Neurons
GMC
Prospero in the nucleus
Basal
Apical
Basal
Apical
Neuroepithelium
Neuroepithelium
Inscutable/Bazooka complex
Glial cells
GCM in the
nucleus
Neuroblast L1
Glioblast M1
gcm mRNA
Neuroglioblast
NB6-4
Mitosis
Numb
SOP
Notch
Notch
Notch
IIa
IIb
Socket Shaft Neuron
Sheath
CP
IZ
VZ
Pial surface
Radial
glia
Notch
Numb
Radial
neuron
Notch
Numb
Notch
Delta
Binding to delta causes
notch cleavages
Notch tail migrates
to nucleus
(a)
(b)
(d)
(c)
called
lateral inhibition
.I
nt
h
ep
r
o
c
e
s
s
of Notch signaling, the cytoplasmic re-
gion is cleaved and transported into the
cell nuclei to switch on the downstream
target genes (Fig. 9d). Signaling may be
modiĀ±ed by Numb (an intrinsic determi-
nant localized at the cytoplasmic side of
cell membrane and/or Fringe (a mem-
ber of glycosyltransferase). Although the
initiation of this process is stochastic, a
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