Brain Development
97
specifc binding property: cells with a par-
ticular subclass oF cadherin can generally
adhere to those with the same subclass
oF cadherin, although some pairs oF cad-
herins show heterotypic bindings. Owing
to this characteristic, iF cells with diFFerent
cadherin subclasses are mixed, they sort
out From each other in
in vitro
aggregation
assays (±ig. 5b). The restricted expression
pattern oF ±-cadherin at the
sulcus limitans
NC
Transmembrane domain
p120ctn
PTP1B
b
-catenin
a
-catenin
vinculin etc.
IQGAP1
Cdc42, Rac1
Actin filament
Wnt pathway
?
EC1
EC2
EC3
EC4
EC5
Cadherin extracellular domains (EC1~5)
Ca
2
+
(a)
(b)
E
E
+
PE
+
N E
+
P
+
N
(c)
7
6B
N
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