88
Brain Development
6.2
Contact-independent (Long-range) Axon Guidance Mechanisms
118
6.3
Plasticity of the Neuronal Circuit-potentiation of Synaptic
Transmission
119
7
How can Molecular Functions in Complex Tissues be Studied?
120
7.1
Loss-of-function Studies
120
7.2
Gain-of-function Studies
121
Acknowledgments
123
Bibliography
123
Books and Reviews
123
Primary Literature
123
Keywords
Neural induction
The Frst step involved in forming neural tissue.
Early patterning
Steps involved in dividing neural tissue along the A–P and D–V axes.
Differentiation
Generation of distinct types of cells and/or cellular organization (e.g. nuclei, layers, and
so on) in the patterned tissue.
Wiring
±ormation of cell processes and connections into functional neuronal circuits.
¥
Thehumanb
ra
ini
sanin
t
r
ica
teo
rganw
i
thove
rahund
redb
i
l
l
ionce
l
l
s
.B
ra
in
activity is precisely coordinated to generate electrical and hormonal signals that
control basic body functions, movement, awareness, and behaviors. Intriguingly,
the incredible complexity of the brain is formed from a simple cellular sheet
called the
neural plate
. A progressive series of precisely controlled morphogenetic
movements, in combination with cell proliferation, differentiation, and speciFcation
of regional character, generates functionally distinct brain structures. In this article, I
summarize some of the crucial events happening at the cellular and molecular levels
during neural development to help understand the complex processes implicated in
vertebrate brain organization.
previous page 762 Encyclopedia of Molecular Cell Biology and Molecular Medicine read online next page 764 Encyclopedia of Molecular Cell Biology and Molecular Medicine read online Home Toggle text on/off