72
Biotransformations of Drugs and Chemicals
McDonagh, A.F.,
Palma, L.A.,
Lightner, D.A.
(1980) Blue light and bilirubin excretion,
Science
208
, 145–151.
M¨uhlebach, S.,
Bickel, M.H.
(1981)
Pharma-
cokinetics in rats of 2,4,5,2
0
,4
0
,5
0
-hexachloro-
biphenyl, an unmetabolizable lipophilic model
compound,
Xenobiotica
11
, 249–257.
Nagata, K., Yamazoe, Y. (2000) Pharmacogenet-
ics of sulfotransferase,
Annu. Rev. Pharmacol.
Toxicol.
40
, 159–176.
Nagata, K.,
Yamazoe, Y.
(2002)
Genetic
polymorphism of human cytochrome P450
involved in drug metabolism,
Drug Metab.
Pharmacokinet.
17
, 167–189.
Nelson, S.D. (1990) Molecular mechanisms of
the hepatotoxicity caused by acetaminophen,
Semin. Liv. Dis.
10
, 267–278.
Nelson, D.R., Kamataki, T., Waxman, D.J., Guen-
gerich, F.P., Estabrook, R.W., Feyereisen, R.,
Gonzalez, F.J., Coon, M.J., Gunsalus, I.C., Go-
toh, O., Okuda, K., Nebert, D.W. (1993) The
P450 superfamily: update on new sequences,
gene mapping, accession numbers, early triv-
ial names or enzymes, and nomenclature,
DNA Cell Biol
.
12
, 1–51.
Nordling, E.,
Persson, B.,
Jornvall, H.
(2002)
Differential
multiplicity
of
MDR
alcohol
dehydrogenases: enzyme genes in the human
genome versus those in organisms initially
studied,
Cell. Mol. Life Sci.
59
, 1070–1075.
Ohno, Y.,
Ormstad, K.,
Ross, D., Orrenius, S.
(1984) Mechanism of allyl alcohol toxicity and
the protective effects of low-molecular weight
thiols, studied with isolated rat hepatocytes,
Toxicol. Appl. Pharmacol.
78
, 169–179.
Okita, R.T., Okita, J.R. (2001) Cytochrome P450
4A fatty acid omega hydroxylases,
Curr. Drug
Metab.
2
, 265–281.
Paine, M.J.I., Scrutton, N.S., Munro, A.W.,
Roberts, G.C.K., Wolf, C.R. (2004) Electron
transfer partners of cytochrome P450, ibid
reference 5, in press.
Patsalos, P.N.,
Perucca, E.
(2003)
Clinically
important
drug
interactions
in
epilepsy:
general features and interactions between
antiepileptic drugs,
Lancet Neurol
.
2
, 347–356.
Radel, M., Goldman, D. (2001) Pharmacogenet-
ics of alcohol response and alcoholism: the
interplay of genes and environmental factors
in thresholds for alcoholism,
Drug Metab. Dis-
pos.
29
, 489–494.
Raucy, J.,
Warfe, L.,
Yueh, M.F.,
Allen, S.W.
(2002) A cell-based reporter gene assay for
determining induction of CYP3A4 in a high-
volume system,
J. Pharmacol. Exp. Ther.
303
,
412–423.
Rettie, A.,
Rettenmeier, A.W.,
Howald, W.N.,
Baillie, T.A. (1987) Cytochrome P-450-cata-
lyzed formation of
1
4
-VPA, a toxic metabolite
of valproic acid,
Science
235
, 890–893, 28.
Roberts, S.A. (2001) High-throughput screening
approaches for investigating drug metabolism
and
pharmacokinetics,
Xenobiotica
31
,
557–589.
Salinas, A.E., Wong, M.G. (1999) Glutathione S-
transferases – a review,
Curr. Med. Chem.
6
,
2790309.
Stevens, J.,
Jakoby, W.B.
(1983)
Cysteine
conjugate
β
-lyase,
Mol.
Pharmacol.
23
,
761–765.
Smith, C.V., Jones, D.P., Guenthner, T.M., Lash,
L.H., Lauterburg, B.H. (1996) Compartmenta-
tion of glutathione: Implications for the study
of toxicity and disease,
Toxicol. Appl. Pharma-
col.
140
, 1–12.
Umehara, K., Kudo, S., Hirao, Y., Morita, S.,
Ohtani, T., Uchida, M., Miyamoto, G. (2000)
In
vitro
characterization of the oxidative cleavage
of the octyl side chain of olanexidine, a novel
antimicrobial agent, in dog liver microsomes,
Drug Metab. Dispos.
28
, 1417–1424.
Vaz
,A
.D
.N
.
,Pernecky
,S
.J
.
,Raner
,G
.M
.
,Coon
,
M.J.
(1996)
Peroxo-iron
and
oxenoid-iron
species
as
alternative
oxygenating
agents
in
cytochrome
P450-catalyzed
reactions:
switching
by
threonine-302
to
alanine
mutagenesis of cytochrome P450 2B4,
Proc.
Natl. Acad. Sci. U.S.A.
93
, 4644–4648.
Waxman, D.J., Chang, T.K.H. (1995) Hormonal
regulation of liver cytochrome P450 enzymes,
ibid reference 4, 391–417.
Weber, W.W., Hein, D.W. (1985) N-Acetylation
pharmacogenetics,
Pharmacol. Rev.
37
, 25–79.
Whitlock,
J.P.
Jr.,
Denison,
M.S.
(1995)
Induction
of
cytochrome
P450
enzymes
that metabolize xenobiotics, ibid reference 4,
367–390.
Williams, R.T. (1959)
DetoxiFcation Mechanisms
,
Chapman & Hall, London.
W
i
l
l
i
am
s
,S
.N
.
,D
u
n
h
am
,E
.
,B
r
a
d
±
e
l
d
,C
.A
.
(2003)
Induction
of
cytochrome
P450
enzymes, ibid reference 5, in press.
Xu, W., Bak, S., Decker, A., Paquette, S.M., Fey-
ereisen, R., Galbraith, D.W. (2001) Microarray-
based analysis of gene expression in very large
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