51
Biotransformations of Drugs and
Chemicals
Paul R. Ortiz de Montellano
Department of Pharmaceutical Chemistry, University of California,
San Francisco, CA, USA
1
General Purpose of Xenobiotic and Drug Metabolism
52
2
ClassiFcation and Properties of Enzymes of Xenobiotic Metabolism
53
3
Phase I Enzymes
54
3.1
Cytochrome P450 and Flavin Monooxygenases
54
3.2
Monoamine Oxidase
57
3.3
Alcohol and Aldehyde Dehydrogenases
57
3.4
Esterases and Amidases
59
3.5
Epoxide Hydrolases
59
4P
h
a
s
e
I
I
E
n
z
y
m
e
s
6
0
4.1
Glucuronyl Transferases
60
4.2
Sulfotransferases
63
4.3
N
-Acyl Transferases
64
4.4
Methyl Transferases
65
4.5
Glutathione Transferases
66
5
Xenobiotic Metabolism and Toxicity
68
6
Therapeutic Aspects of Drug Metabolism
69
7
Species Differences and Extrapolation to Humans
69
8
High-throughput Methods in Drug Metabolism Studies
70
Bibliography
70
Books and Reviews
70
Primary Literature
70
Encyclopedia of Molecular Cell Biology and Molecular Medicine, 2nd Edition
. Edited by Robert A. Meyers.
Copyright
2004 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
ISBN: 3-527-30544-0
previous page 725 Encyclopedia of Molecular Cell Biology and Molecular Medicine read online next page 727 Encyclopedia of Molecular Cell Biology and Molecular Medicine read online Home Toggle text on/off