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Bioorganic Chemistry
Keywords
Solid-phase Oligonucleotide Synthesis
The primary technique used for chemical synthesis of oligonucleotides via sequential
addition of monomers to a growing, resin-bound chain.
Phosphorothioate-containing DNA
A nuclease-resistant form of DNA in which one of the two unesteriFed phosphate
oxygens is replaced with a sulfur atom.
Enzyme Inhibitors
Molecules that are able to prevent enzyme catalytic action.
Catalytic Antibodies
Antibodies that have been generated to catalyze speciFc chemical reactions.
Transition-state Analogs
Molecules that closely resemble the shape and charge of a reaction’s transition state
(more accurately known as the activated complex).
Combinatorial Chemistry
Method of synthesis of large numbers of molecules by the reaction of sets of monomer
units at multiple positions.
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Bioorganic chemistry is the study of biological systems, utilizing the tools of the
organic chemist, usually including a synthetic component.
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Introduction
Bioorganic chemistry is the study of bio-
logical systems utilizing the tools of the
organic chemist, usually including a syn-
thetic component. Bioorganic chemists
pursue a wide range of activities includ-
ing the study of biomechanisms, enzyme
models, biosynthesis, biomimetic synthe-
sis, molecular recognition, enzymology,
peptide chemistry, nucleic acid chemistry,
immunology, and the design and synthe-
sis of therapeutic agents. Within the past
decade, the classical distinctions among
scientiFc disciplines have gradually faded
so that frequently one Fnds the synthetic
organic chemist making compounds of
biological interest and, conversely, the
biochemist using synthetic techniques to
aid in answering biological questions. In
this article, we discuss some highlights
of bioorganic chemistry ranging from the
more organic to the more biochemical.
Areas of greatest interest to molecular bi-
ologists are emphasized.
Before delving into speciFc topics that
relate bioorganic chemistry to molecular
biology, we will explore in a more general
way the physical and chemical principles
that govern these topics and, indeed, gov-
ern all systems that one can observe in
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