1
Bioorganic Chemistry
Simon H. Friedman
University of Missouri, Kansas City, MO, USA
1
Introduction
2
2
General Principles
3
2.1
Covalent
3
2.2
Noncovalent Interactions
6
2.2.1
Electrostatic
8
2.2.2
Hydrogen Bonding
9
2.2.3
Hydrophobic Effect
10
2.2.4
van der Waals’ Interactions
10
2.2.5
Conformational/ConFgurational Aspects
10
3
Nucleotide Interactions
11
3.1
Oligonucleotides
11
3.2
Small Molecules
13
4
Protein Studies
16
4.1
Enzyme Inhibition
16
4.2
Enzyme Catalysis
18
4.3
Transition-state Analogs and Catalytic Antibodies
20
4.4
Solid-phase Peptide Synthesis
22
5
Combinatorial Chemistry
23
6
Molecular Modeling
27
7
Summary
30
Bibliography
30
Books and Reviews
30
Primary Literature
30
Encyclopedia of Molecular Cell Biology and Molecular Medicine, 2nd Edition
. Edited by Robert A. Meyers.
Copyright
2004 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
ISBN: 3-527-30544-0
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