Biological Regulation by Protein Phosphorylation
671
NMR structural structures are helping to
reveal the molecular basis of enzymatic
activity and substrate speciFcity. In con-
junction with molecular modeling studies,
this structural information can aid in the
rational design of more potent and selec-
tive enzyme inhibitors. These compounds
are helping to deFne further the role of
particular kinases and phosphatases in sig-
nal transduction and in the evaluation of
their suitability as targets for therapeu-
tic intervention in disease. The next few
years represent an exciting time in the
Feld of protein phosphorylation in terms
of seeing how understanding fundamen-
tal biology is enabling the development
of new medicines for the treatment of
human diseases.
See also
Bioorganic Chemistry.
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