66
Aging and Sex, DNA Repair in
Tab. 4
Normal aging: alterations in genes controlling DNA repair or oxidant status but which do not alter life span.
Organism
Genetic
alteration
Pathway
Aging
phenotype
Fertility
Spontaneous
cancer
Effect On
Cellular
ROS
Induced
DNA
damage
Spont.
mutation
Induced
apoptosis
Mouse
XPA defect
NER
Unchanged
a
Unchanged
Increased
liver
cancer
n.t.
n.t.
Increased in
liver, no
change in
brain
n.t.
Mouse
XPC defect
GGR (NER)
Unchanged
a
Unchanged
Unchanged
(when not
exposed to
UV light)
n.t.
n.t.
Increased
n.t.
Fruitfly
ExcessSOD
RemovesROS
Unchanged
Unchanged
n.t.
n.t.
n.t.
n.t.
n.t.
Notes
: ROS: reactive oxygen species; Spont.: spontaneous; n.t.: not tested.
a
Based on observations during the ±rst half of life span.
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