62
Aging and Sex, DNA Repair in
Tab. 3
(
continued
)
Organism
Genetic
Pathway
Aging
Fertility
Spontaneous
Effect on
alteration
phenotype
cancer
Cellular
Induced
Spont.
Induced
ROS
DNA
mutation
apoptosis
damage
Mouse
ERCC1 defect
NER and interstrand
cross-link repair
(HRR)
Early aging
Infertile
No change
n.t.
Increased
Increased
Mouse
p53 overactivated
Increases some p53
functions
Early aging
n.t.
Reduced
n.t.
n.t.
n.t.
Mouse
p53 defect
Blocks all p53
functions,
including NER,
BER and HRR
Early aging
Reduced
Increased
n.t.
Increased
Increased
Mouse
MsrA Defect
Methionine
sulfoxide
reductase
Early aging
n.t.
n.t.
Increased
protein
oxidation
n.t.
n.t.
Notes
: ROS: reactive oxygen species; Spont.: spontaneous; n.t.: not tested.
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