594
Behavior Genes
Tab. 2
Examples of adoption studies of schizophrenia, not age-corrected. (Taken from McGufFn, P., Owen, M. J., O’Donovan, M. C., Thapar, A.,
Gottesman, I. I. (1994)
Seminars in Psychiatric Genetics
, Gaskell, London.)
Study
Typeofstudy
Diagnosis
Geneticrelativesofa
schizophrenic
Not genetically related to
schizophrenic
Heston (1966)
Adoptee
Schizophrenia
10.6% of 47 adoptees who had a
schizophrenic mother
0% of 50 control adoptees
Rosenthal et al.
(1968)
Adoptee
Schizophrenia spectrum
disorder
18.8% of 69 children of
schizophrenics raised by
normals
10.1% of 79 control adoptees
Wender et al.
(1974)
Cross-fostering
Schizophrenia spectrum
disorder
18.8% of 69 children raised by
normals
10.7% of 28 children of controls
raised by future schizophrenics
Kety (1983)
Kety et al. (1994)
Adoptee’s family: national
sample (47 chronic
schizophrenic adoptees)
Chronic and latent
(DSM-II) schizophrenics
15.8% of 279 biological relatives
of adopted-away
schizophrenics
18% of 228 adoptive relatives of
schizophrenics and relatives of
control adoptees
Kendler et al.
(1984, 1994)
Reassessment of Kety’s
data (31 adoptees with
spectrum disorder)
DSM-III schizophrenia,
schizotypal personality
disorder, RDC
schizoaffective disorder,
mainly schizophrenic
14.4% of 209 biological relatives
of adopted-away
schizophrenics (23.5% in
Frst-degree relatives, 9.9% in
second-degree relatives)
3% of 299 adoptive relatives of
schizophrenics and relatives of
control adoptees
Tienari (2000)
Adoptee
Schizophrenic/paranoid
psychosis
6.7% of 164 adoptees who had
schizophrenic biological
parents
2.0% of 197 control adoptees
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