554
Bacterial Pathogenesis, Molecular Basis of
Keywords
Virulence
The relative ability of an organism to cause disease.
Pathogen
Organisms capable of causing disease.
Adhesin
A molecule used by a bacterial cell to adhere to a surface.
Colonization
The ability of a pathogen to adhere to host cells or surfaces and to multiply within
the host.
Quorum sensing
A regulatory mechanism by which the expression of various genes is coordinated to
population density via the interaction of a receptor protein and a small organic
signaling molecule.
Antimicrobial Resistance
The ability of a bacterial pathogen to become refractory to the actions of a given
antimicrobial compound.
Pathogenic Cycle
The common steps that pathogens need to undertake to establish themselves within a
host and survive.
¥
The incidence of infectious disease due to bacteria continues to be a leading
cause of morbidity and mortality worldwide despite advances in public health
measures, modern medicine, and the availability of myriad antimicrobial drugs.
Those organisms that are able to cause disease are referred to as
pathogens
.These
organisms have evolved many mechanisms to subvert the immune defenses of the
human host and usurp usual host cell processes to allow their own proliferation and
persistence during infections. In addition to uncovering the inner working of both
bacterial and host cells, the elucidation of these processes provides the potential for
the development of new therapeutic approaches.
previous page 554 Encyclopedia of Molecular Cell Biology and Molecular Medicine read online next page 556 Encyclopedia of Molecular Cell Biology and Molecular Medicine read online Home Toggle text on/off