53
Aging and Sex, DNA Repair in
Carol Bernstein and Harris Bernstein
University of Arizona, Tucson, AZ, USA
1
The DNA Damage Theory of Aging
56
1.1
Occurrence of DNA Damage and Pathways of DNA Repair
56
1.2
Consequences of Unrepaired DNA Damage
56
1.3
Life Span Extension by Genetic Alterations that Increase
DNA Repair, Reduce Oxidative Damage, or Reduce Cell Suicide
(Apoptosis) due to DNA Damage
57
1.4
Premature Aging Associated with Defects in DNA
Repair or Increased Oxidant Status
63
1.5
Normal Aging in spite of Certain Defects in DNA Repair or Increases
in Antioxidant Enzyme Production
64
1.6
Negative Correlation between Mitochondrial ROS
Production and Life Span
65
1.7
Other Work Indicating the Central Role of DNA Damage
and DNA Repair in Aging
67
1.8
Calorie Restriction and Aging
67
1.9
General Strategies for Coping with DNA Damage
and Some Consequences
68
1.10
Potential Immortality of the Germ Line
69
2
DNA-repair Pathways and Their Relation to Aging
70
2.1
NER (Nucleotide Excision Repair)
70
2.2
BER (Base Excision Repair)
70
2.3
HRR (Homologous Recombinational Repair)
73
2.4
NHEJ (Nonhomologous End Joining)
75
2.5
MGMT (O
6
-Methylguanine-DNA Methyltransferase)
76
2.6
Enzymes of DNA Repair Pathways and Enzymes Regulating
DNA Damage–inducing ROS Contribute to Determination of Aging
77
Encyclopedia of Molecular Cell Biology and Molecular Medicine, 2nd Edition
. Edited by Robert A. Meyers.
Copyright
2004 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
ISBN: 3-527-30543-2
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