Autoantibodies and Autoimmunity
473
Tab. 4
Examples of animal models of autoantibody production.
Model
Animal
Human disease
Autoantibody specifcity
Spontaneous
NZB
Mouse
Hemolytic anemia
Erythrocyte
(NZB
×
NZW) F1
Mouse
SLE
Chromatin, DNA
MRL-
lpr
/
lpr
Mouse
SLE
Chromatin, DNA, Sm,
ribosome
MRL-
+
/
+
Mouse
SLE
Chromatin, DNA, Sm
BXSB
Mouse
SLE
Chromatin, DNA
Obese strain
(white leghorn
chicken)
Bird
Thyroiditis
Thyroglobulin
Induced by
exogenous agents
Chronic GVHD
Mouse
SLE
DNA, chromatin, snRNP,
ribosome
Mercuric chloride
Mouse (H-2
s
)
Scleroderma
a
(immune-
complex
nephritis)
Fibrillarin (Box C/D snoRNP)
Mercuric chloride
Mouse (non-H-2
restricted)
SLE
Chromatin
Mercuric chloride
Rat (RT1
n
)
Immune-complex
nephritis
GBM
Pristane
Mouse
SLE
DNA, Sm, RNP, Su
Direct
immunization
(antigen)
EAT
(thyroglobulin)
Rabbit, mouse
(H-2
k
,
s
,
or q
)
Thyroiditis
Thyroglobulin
GMB nephritis
(GBM)
Sheep, mouse
Immune-complex
nephritis
GBM
EMG
(acetylcholine
receptor)
Lewis rat
Myasthenia gravis
Acetylcholine receptor
Gene mutation
C1q knockout
Mouse (MRL-
+
/
+
)
SLE
DNA, rheumatoid factor
Dnase1 knockout
Mouse
SLE
Chromatin, DNA
SAP knockout
Mouse
SLE
Chromatin, DNA
c-mer knockout
Mouse
SLE
Chromatin
IFN-
γ
transgenic
Mouse
SLE
DNA, histones
a
Autoantibody speci±city is speci±c for scleroderma, but a scleroderma-like disease has not been
described in mice treated with mercuric chloride.
Notes
: GVHD: graft-versus-host disease; GMB: glomerular basement membrane; EAT: experimental
autoimmune thyroiditis; EMG: experimental myasthenia gravis; C1q: component of serum
complement; Dnase1: deoxyribonuclease 1; SAP: serum amyloid P component; c-mer:
tyrosine kinase.
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