Antitumor Steroids
453
HO
Me
OH
EE-
OH
CC
CHO
Co
2
(CO)
6
OH
CC
CH
2
OH
Co
2
(CO)
6
EE
Cr(CO)
3
EE
Re(CO)
3
EE
W(CO)
3
Me
EE
Ru
Fe
EE
N
S
S
Pt
Cl
Me
Me
EE
+
Cl
N
S
S
Pd
Cl
Me
Me
EE
+
Cl
N
S
S
Pd
Cl
Bn
Bn
EE
+
Cl
N
S
Cl
Re
CO
Me
EE
N
O
O
Zn
EE
CO
CO
S
Me
O
O
X
N
O
O
Pt
EE
O
O
X
N
S
S
Ni
Me
Me
EE
Cl
Cl
N
S
S
Zn
Me
Me
EE
Br
Br
Fig. 8
Organometallic E
2
derivatives – chemical formulas of 17
α
ethynyl E
2
(EE)
derivatives described in Sect. 4.1.3.
4.2
Radiolabeled Estradiol Derivatives
ThepresenceofER-positiveand-negative
cells in all tumors led to the concept of
using receptor-directed radiochemicals of
which the range of radiation is larger
than one cell diameter. Compounds of
this type would be of great interest since
their action would not restrict solely to
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