403
Antisense Oligonucleotides as
Potential Drugs
Joachim W. Engels
1
and Fritz Eckstein
2
1
Goethe-Universitat Institut f
..
ur Organische Chemie und Chemische
Biologie (OCCB), Frankfurt am Main, Germany
2
Max-Planck-Insitut f
..
ur Experimentelle Medizin, G
..
ottingen, Germany
1
Introduction
405
2
Chemical Modifcation oF Oligonucleotides
406
2.1
Unmodifed Oligonucleotides
406
2.2
Phosphorothioates
406
2.3
Alkylphosphonates
406
2.4
2
0
-
O
-Modifcation
408
2.5
Sterically Locked Nucleic Acids
408
2.6
N3
0
-P5
0
-Phosphoramidates
409
2.7
Morpholino Oligonucleotides
409
2.8
Peptide Nucleic Acids (PNA)
409
2.9
Oligonucleotide Conjugates
409
2.10
5
0
-end Conjugates
409
2.11
3
0
-end Conjugates
409
3
Mechanism oF Action
410
4
Positioning
410
5
Delivery
411
6
Application
411
7
RNA InterFerence
412
8
Ribozymes
413
Encyclopedia of Molecular Cell Biology and Molecular Medicine, 2nd Edition
. Edited by Robert A. Meyers.
Copyright
2004 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
ISBN: 3-527-30543-2
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