Antigen Presenting Cells (APCs)
T Cell Priming and Polarization
Priming of CD8
T Helper Cell Polarization
Immune Evasion and Plasticity of DCs
DCs in Immunotherapy
Books and Reviews
Any piece of a substance that can induce a speciFc immune response or reacts to a
speciFc antibody or T cell.
Proteins, such as integrins, selectins, members of the Ig superfamily, or CD44, that
mediate the binding of one cell to other cells or to the extracellular matrix.
A substance that enhances the immune response to antigens and is therefore used in
A process by which the immune system (e.g. T cells, B cells) is switched on to deal with
Secondary signals provided to T cells by costimulatory molecules (e.g. CD80, CD86) on
antigen presenting cells. Regulated expression of costimulatory molecules allows T-cell
activation in inﬂammation but not under healthy conditions.
Denotes a deoxynucleotide motif in bacterial DNA that differs in sequence and
methylation state from mammalian DNA. It binds to and activates certain subsets of
A term popularized by Matzinger, that covers the various signals from damaged tissues
or from microbial products that trigger activation of dendritic cells.