Antigen Presenting Cells (APCs)
355
10.5
T Cell Priming and Polarization
395
10.5.1
Priming of CD8
+
and CD4
+
T Cells
395
10.5.2
T Helper Cell Polarization
396
10.6
Immune Evasion and Plasticity of DCs
397
10.7
DCs in Immunotherapy
398
Bibliography
399
Books and Reviews
399
Primary Literature
400
Keywords
Antigen
Any piece of a substance that can induce a speciFc immune response or reacts to a
speciFc antibody or T cell.
Adhesion Molecules
Proteins, such as integrins, selectins, members of the Ig superfamily, or CD44, that
mediate the binding of one cell to other cells or to the extracellular matrix.
Adjuvant
A substance that enhances the immune response to antigens and is therefore used in
immunizations.
Activation
A process by which the immune system (e.g. T cells, B cells) is switched on to deal with
an infection.
Costimulation
Secondary signals provided to T cells by costimulatory molecules (e.g. CD80, CD86) on
antigen presenting cells. Regulated expression of costimulatory molecules allows T-cell
activation in inflammation but not under healthy conditions.
CpG
Denotes a deoxynucleotide motif in bacterial DNA that differs in sequence and
methylation state from mammalian DNA. It binds to and activates certain subsets of
dendritic cells.
Danger
A term popularized by Matzinger, that covers the various signals from damaged tissues
or from microbial products that trigger activation of dendritic cells.
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