Antibody Molecules, Genetic Engineering of
349
Hanes, J., Jermutus, L., Weber-Bornhauser, S.,
Bosshard, H.R., Pl¨uckthun, A. (1998) Ribo-
some display efFciently selects and evolves
high-afFnity antibodies
in vitro
from immune
libraries,
Proc. Natl. Acad. Sci. U.S.A.
95
,
14130–14135.
He, M., Taussig, M.J. (1997) Antibody-ribosome-
mRNA (ARM) complexes as efFcient selection
particles for
in vitro
display and evolution of
antibody combining sites,
Nucleic Acids Res.
25
, 5132–5134.
Higuchi, K., Araki, T., Matsuzaki, O., Sato, A.,
Kanno, K., Kitaguchi, N., Ito, H. (1997) Cell
display library for gene cloning of variable
regions of human antibodies to hepatitis B
surface antigen,
J. Immunol. Methods
202
,
193–204.
Holliger, P.,
Prospero, T.,
Winter, G.
(1993)
‘‘Diabodies’’: small bivalent and bispeciFc
antibody fragments,
Proc. Natl. Acad. Sci.
U.S.A.
90
, 6444–6448.
H
u
,S
.
,S
h
i
v
e
l
y
,L
.
,R
a
u
b
i
t
s
c
h
e
k
,A
.
,
Sherman,
M.,
Williams, L.E.,
Wong, J.Y.,
Shively, J.E.,
Wu, A.M.
(1996)
Minibody:
a
novel
engineered
anti-carcinoembryonic
antigen antibody fragment (single-chain ±v-
CH3) which exhibits rapid, high-level targeting
of xenografts,
Cancer Res.
56
, 3055–3061.
Hudson, P.J., Kortt, A.A. (1999) High avidity
sc±v multimers; diabodies and triabodies,
J.
Immunol. Methods
231
, 177–189.
Iliades, P.,
Kortt, A.A.,
Hudson, P.J.
(1997)
Triabodies: single chain ±v fragments without
a linker form trivalent trimers,
FEBS Lett.
409
,
437–441.
Jaffers, G.J.,
±uller, T.C.,
Cosimi, A.B.,
Rus-
sell, P.S., Winn, H.J., Colvin, R.B. (1986) Mon-
oclonal antibody therapy. Anti-idiotypic and
non-anti-idiotypic antibodies to OKT3 arising
despite intense immunosuppression,
Trans-
plantation
41
, 572–578.
James,
N.D.,
Atherton,
P.J.,
Jones, J.,
Howie, A.J., Tchekmedyian, S., Curnow, R.T.
(2001) A phase II study of the bispeciFc
antibody MDX-H210 (anti-HER2
×
CD64)
with GM-CS± in HER2
+
advanced prostate
cancer,
Br. J. Cancer
85
, 152–156.
Jespers, L.S., Roberts, A., Mahler, S.M., Winter,
G., Hoogenboom, H.R. (1994) Guiding the
selection of human antibodies from phage
display
repertoires
to
a
single
epitope
of
an
antigen,
Biotechnology
(NY)
12
,
899–903.
Kohler, G.,
Milstein, C.
(1975)
Continuous
cultures of fused cells secreting antibody of
predeFned speciFcity,
Nature
256
, 495–497.
Kontsekova, E.,
Kolcunova, A.,
Kontsek, P.
(1992) Quadroma-secreted bi(interferon alpha
2–peroxidase)
speciFc
antibody
suitable
for one-step immunoassay,
Hybridoma
11
,
461–468.
Kortt, A.A., Lah, M., Oddie, G.W., Gruen, C.L.,
Burns, J.E.,
Pearce, L.A.,
Atwell, J.L.,
Mc-
Coy, A.J., Howlett, G.J., Metzger, D.W., Web-
ster, R.G., Hudson, P.J. (1997) Single-chain
±v fragments of anti-neuraminidase antibody
NC10 containing Fve- and ten-residue linkers
form dimers and with zero- residue linker a
trimer,
Protein Eng.
10
, 423–433.
Kostelny, S.A.,
Cole, M.S.,
Tso, J.Y.
(1992)
±ormation of a bispeciFc antibody by the use of
leucine zippers,
J. Immunol.
148
, 1547–1553.
Kuus-Reichel, K., Grauer, L.S., Karavodin, L.M.,
Knott, C., Krusemeier, M., Kay, N.E. (1994)
Will immunogenicity limit the use, efFcacy,
and
future
development
of
therapeutic
monoclonal
antibodies?
Clin.
Diagn.
Lab.
Immunol.
1
, 365–372.
Leget, G.A.,
Czuczman, M.S.
(1998)
Use
of
rituximab, the new ±DA-approved antibody,
Curr. Opin. Oncol.
10
, 548–551.
Lewis, L.D., Cole, B.±., Wallace, P.K., ±isher, J.L.,
Waugh, M.,
Guyre, P.M.,
±anger, M.W.,
Curnow, R.T., Kaufman, P.A., Ernstoff, M.S.
(2001) Pharmacokinetic-pharmacodynamic re-
lationships of the bispeciFc antibody MDX-
H210 when administered in combination with
interferon gamma: a multiple-dose phase-I
study in patients with advanced cancer which
overexpresses HER-2/neu,
J. Immunol. Meth-
ods
248
, 149–165.
L
i
u
,
S
.
J
.
,S
h
e
r
,
Y
.
P
.
,T
i
n
g
,
C
.
C
.
,L
i
a
o
,
K
.
W
.
,
Yu, C.P., Tao, M.H. (1998) Treatment of B-cell
lymphoma with chimeric IgG and single-chain
±v
antibody-interleukin-2
fusion
proteins,
Blood
92
, 2103–2112.
Lloyd, ±. Jr., Goldrosen, M. (1991) The produc-
tion of a bispeciFc anti-CEA, anti-hapten
(4-amino-phthalate) hybrid-hybridoma,
J. Natl.
Med. Assoc.
83
, 901–904.
Mallender, W.D., Voss, E.W. Jr. (1994) Construc-
tion, expression, and activity of a bivalent
bispeciFc single-chain antibody,
J. Biol. Chem.
269
, 199–206.
Marasco, W.A. (1997) Intrabodies: turning the
humoral
immune
system
outside
in
for
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