Antibody Molecules, Genetic Engineering of
347
antibodies. The ability to express foreign
DNA
in
a
variety
of
host
cells
has
made it possible to produce chimeric,
humanized, and human antibodies as
well as antibodies with novel structures
and functional properties in quantities
sufFciently large for many applications
including clinical therapy. The available
experience suggests that antibody-based
therapies can be successfully developed
for use in clinical situations in which no
alternative effective therapy is available.
However,
continued
progress
in
the
development of antibody-based therapies
will require extensive research to further
deFne the mechanism of antibody action
and
on
how
to
optimally
use
the
novel proteins with unique functional
properties.
See also
Genetics, Molecular Basis
of; Medicinal Chemistry.
Bibliography
Books and Reviews
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(2002)
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