329
Antibody Molecules, Genetic
Engineering of
Manuel L. Penichet and Sherie L. Morrison
Department of Microbiology, Immunology, and Molecular Genetics,
University of California, Los Angeles, CA, USA
1
Antibody Structure and Engineering
331
1.1
The Basic Structure of Antibodies
331
1.2
Classes and Subclasses of Antibodies
332
2
From Mouse to Human Antibodies
334
2.1
Murine Monoclonal Antibodies
334
2.2
Chimeric Antibodies
336
2.3
Humanized Antibodies
337
2.4
Human Monoclonal Antibodies in Mice
337
3
In Vitro
Antibody Production by Phage Libraries
338
4
Further Genetic Modi±cations of Antibodies
340
4.1
Engineering Antibody Fragments: Monovalent, Bivalent,
and Multivalent scFvs
340
4.2
Bispeci±c Antibodies
342
4.3
Polymers of Monomeric Antibodies
343
4.4
Antibody Fusion Proteins
344
5
Expression Systems
346
6
Conclusion
346
Bibliography
347
Books and Reviews
347
Primary Literature
347
Encyclopedia of Molecular Cell Biology and Molecular Medicine, 2nd Edition
. Edited by Robert A. Meyers.
Copyright
2004 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
ISBN: 3-527-30543-2
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