23
Aggregation, Protein
Jeannine M. Yon
Universit´
edePar
is-sud,Orsay,France
1
Introduction
25
2
Protein Folding, Misfolding, and Aggregation
25
2.1
The New View of Protein Folding
25
2.2
Detection of Aggregates during the Refolding Process
27
2.2.1
Transient Aggregation
27
2.2.2
Irreversible Aggregation
29
2.3
Mechanisms of Protein Aggregation
30
3
Protein Folding in the Cellular Environment
34
3.1
Molecular Crowding in the Cells
34
3.2
The Role of Molecular Chaperones
34
4
Protein Aggregation in the Cellular Environment
40
4.1
The Formation of Inclusion Bodies
40
4.1.1
Occurrence of Inclusion Bodies
40
4.1.2
Characteristics of Inclusion Bodies
41
4.1.3
Strategies for Refolding Inclusion Body Proteins
43
4.2
The Formation of Amyloid Fibrils and its Pathological Consequences
45
Bibliography
49
Books and Reviews
49
References of Primary Literature
49
Encyclopedia of Molecular Cell Biology and Molecular Medicine, 2nd Edition
. Edited by Robert A. Meyers.
Copyright
2004 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
ISBN: 3-527-30543-2
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