206
Alzheimer’s Disease
Schenk, D., Barbour, R., Dunn, W., Gordon, G.,
Grajeda, H.,
Guido, T.,
Hu, K.,
Huang, J.,
Johnson-Wood, K., Khan, K., Kholodenko, D.,
Lee, M., Liao, Z., Lieberburg, I., Motter, R.,
Mutter,L.,Soriano,F.,Shopp,G.,Vasquez, N.,
Vandevert, C., Walker, S., Wogulis, M., Yed-
nock, T.,
Games, D.,
Seubert, P.
(1999)
Immunization
with
amyloid-
β
attenuates
Alzheimer-disease-like
pathology
in
the
PDAPP mouse,
Nature
400
, 173–177.
Scheuner, D., Eckman, C., Jensen, M., Song, X.,
Citron, M., Suzuki, N., Bird, T.D., Hardy, J.,
Hutton, M.,
Kukull, W.,
Larson, E.,
Levy-
Lahad, E.,
Viitanen, M.,
Peskind, E.,
Poor-
kaj, P., Schellenberg, G., Tanzi, R., Wasco, W.,
Lannfelt, L., Selkoe, D., Younkin, S. (1996) Se-
creted amyloid
β
-protein similar to that in the
senile plaques of Alzheimer’s disease is in-
creased
in vitro
by the presenilin 1 and 2 and
APP mutations linked to familial Alzheimer’s
disease,
Nat. Med.
2
, 864–870.
Seubert, P.,
Oltersdorf, T.,
Lee, M.G.,
Bar-
bour, R., Blomquist, C., Davis, D.L., Bryant, K.,
Fritz, L.C.,
Galasko, D.,
Thal, L.J.
(1993)
Secretion
of
β
-amyloid
precursor
protein
cleaved at the amino terminus of the
β
-amyloid
peptide,
Nature
361
, 260–263.
Seubert, P., Vigo-Pelfrey, C., Esch, F., Lee, M.,
Dovey, H., Davis, D., Sinha, S., Schlossma-
cher, M., Whaley, J., Swindlehurst, C. (1992)
Isolation and quanti±cation of soluble Alzhei-
mer’s
β
-peptide from biological fluids,
Nature
359
, 325–327.
Sherrington, R.,
Rogaev, E.I.,
Liang, Y.,
Ro-
gaeva, E.A., Levesque, G., Ikeda, M., Chi, H.,
Lin, C., Li, G., Holman, K. (1995) Cloning of
a gene bearing missense mutations in early-
onset familial Alzheimer’s disease,
Nature
375
,
754–760.
Shoji, M., Golde, T.E., Ghiso, J., Cheung, T.T.,
Estus, S.,
Shaffer, L.M.,
Cai, X.D.,
McKay,
D.M., Tintner, R., Frangione, B. (1992) Pro-
duction of the Alzheimer amyloid
β
protein
by normal proteolytic processing,
Science
258
,
126–129.
Sinha, S., Anderson, J.P., Barbour, R., Basi, G.S.,
Caccavello, R., Davis, D., Doan, M., Dovey,
H.F., Frigon, N., Hong, J., Jacobson-Croak, K.,
Jewett, N., Keim, P., Knops, J., Lieberburg, I.,
Power, M.,
Tan, H.,
Tatsuno, G.,
Tung, J.,
Schenk, D., Seubert, P., Suomensaari, S.M.,
Wang, S., Walker, D., John, V. (1999) Puri±ca-
tion and cloning of amyloid precursor protein
β
-secretase from human brain,
Nature
402
,
537–540.
Skovronsky, D.M.,
Zhang, B.,
Kung, M.-P.,
Kung, H.F.,
Trojanowski, J.Q.,
Lee, V.M.
(2000)
In vitro
detection of amyloid plaques in
a mouse model of Alzheimer’s disease,
Proc.
Natl. Acad. Sci. U.S.A.
97
, 7609–7614.
Stenh, C., Nilsberth, C., Hammarback, J., Eng-
vall, B., Naslund, J., Lannfelt, L. (2002) The
Arctic mutation interferes with processing of
the amyloid precursor protein,
Neuro Report
13
, 1857–1860.
Strittmatter, W.J.,
Saunders, A.M.,
Schme-
chel, D., Pericak-Vance, M., Enghild, J., Salve-
sen, G.S., Roses, A.D. (1993) Apolipoprotein
E: high-avidity binding to
β
-amyloid and
increased frequency of type 4 allele in late-
onset familial Alzheimer disease,
Proc. Natl.
Acad. Sci. U.S.A.
90
, 1977–1981.
Sturchler-Pierrat, C., Abramowski, D., Duke, M.,
Wiederhold, K.H., Mistl, C., Rothacher, S., Le-
dermann, B., Burki, K., Frey, P., Paganetti,
P.A., Waridel, C., Calhoun, M.E., Jucker, M.,
Probst, A., Staufenbiel, M., Sommer, B. (1997)
Two amyloid precursor protein transgenic
mouse models with Alzheimer disease-like
pathology,
P
r
o
c
.N
a
t
l
.A
c
a
d
.S
c
i
.U
.S
.A
.
94
,
13287–13292.
Sturchler-Pierrat, C.,
Staufenbiel, M.
(2000)
Pathogenic
mechanisms
of
Alzheimer’s
disease analyzed in the APP23 transgenic
mouse model,
Ann. N. Y. Acad. Sci.
920
,
134–139.
Suzuki, N., Cheung, T.T., Cai, X.D., Odaka, A.,
O
t
vo
s
,L
.
,E
ckman
,C
.
,Go
lde
,T
.E
.
,Younk
in
,
S.G. (1994) An increased percentage of long
amyloid
β
protein secreted by familial amyloid
β
protein precursor (
β
APP717) mutants,
Science
264
, 1336–1340.
Tanzi, R.E., Gusella, J.F., Watkins, P.C., Bruns,
G.A., St. George-Hyslop, P., Van Keuren, M.L.,
Patterson, D., Pagan, S., Kurnit, D.M., Neve,
R.L. (1987) Amyloid
β
protein gene: cDNA,
mRNA
distribution,
and
genetic
linkage
near
the
Alzheimer
locus,
Science
235
,
880–884.
Terry, R.D.,
Masliah, E.,
Salmon, D.P.,
But-
ters, N., DeTeresa, R., Hill, R., Hansen, L.A.,
Katzman, R. (1991) Physical basis of cogni-
tive alterations in Alzheimer’s disease: synapse
loss is the major correlate of cognitive impair-
ment,
Ann. Neurol.
30
, 572–580.
previous page 206 Encyclopedia of Molecular Cell Biology and Molecular Medicine read online next page 208 Encyclopedia of Molecular Cell Biology and Molecular Medicine read online Home Toggle text on/off