1
Adipocytes
Todd Leff
1
and James G. Granneman
1
,
2
1
Department of Pathology, Wayne State University School of Medicine,
Detroit, MI, USA
2
Department of Psychiatry, Wayne State University School of Medicine, Detroit,
MI, USA
1
Introduction – Adipocytes and the Regulation of Metabolism
3
2
Physiology of the Adipocyte
4
2.1
Absorption and Storage of Circulating Lipid
4
2.2
Mobilization and Release of Stored Lipid into the Circulation
5
2.3
Regulatory Mechanisms that Balance Lipid Storage and Utilization
6
2.4
Adipose Tissue as an Endocrine Organ
6
3
Developmental Origin of Adipocytes
9
3.1
Adipose Tissue Development and Plasticity
9
3.2
Differentiation of Adipocytes from Precursor Cells
11
4
Adipose Dysfunction and Metabolic Disease
13
4.1
Obesity – Too Much Fat
14
4.2
Lipodystrophy – Too Little Fat
15
5
The Adipocyte as a Therapeutic Target for Metabolic Disease
15
5.1
Antidiabetic PPAR
γ
Ligands Act on Adipocytes
16
Bibliography
18
Books and Reviews
18
Primary Literature
19
Encyclopedia of Molecular Cell Biology and Molecular Medicine, 2nd Edition
. Edited by Robert A. Meyers.
Copyright
2004 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
ISBN: 3-527-30543-2
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