Alzheimer’s Disease
181
Senile Plaques
Complex extracellular deposits abundant in the brains of AD patients. The main
proteinaceous component of plaques is amyloid-
β
peptide.
Susceptibility Locus/Gene
A region of a chromosome or a speciFc gene that may influence the risk to a certain
condition/disease.
Familial Alzheimer’s Disease
Transmitted as an autosomal dominant trait; usually has an age of onset
<
60 years.
Sporadic Alzheimer’s Disease
Shows modest familial clustering and probably results from the synergistic action of
genetic and environmental factors. Usually has an age of onset
>
60 years.
Abbreviations
A
ββ
-amyloid peptide
AD
Alzheimer’s disease
AICD
APP Intracellular domain
APLP
amyloid precursor-like protein
APOE
apolipoprotein E
APP
β
-amyloid precursor protein
BBB
blood brain barrier
CAA
cerebral amyloid angiopathy
CNS
central nervous system
CT±
C-terminal fragment
±AD
familial Alzheimer’s disease
±TDP-17
frontotemporal dementia with parkinsonism linked to chromosome 17
KPI
Kunitz-type protease inhibitor
MT
microtubule
N±T
neuroFbrillary tangles
NSAID
nonsteroidal anti-inflammatory drugs
NT±
N-terminal fragment
PDG±
platelet-derived growth factor
PH±
paired helical Flaments
PS
presenilin
TM
transmembrane
