180
Alzheimer’s Disease
5
Potential Treatments
199
5.1
Secretase Inhibitors
200
5.2
Vaccine Approaches
201
5.3
Other Therapeutic Approaches
201
6
Summary
202
Bibliography
202
Books and Reviews
202
Primary Literature
202
Keywords
Association Study
Tests for differences in allele or genotype frequencies between unrelated, affected, and
unaffected individuals.
Autosomal Dominant Trait
A phenotype that is expressed in a heterozygote, which maps to a chromosome other
than the sex chromosomes.
β
-secretase
Also known as BACE1; a transmembrane aspartyl protease involved in processing of
APP-generating N-terminal end of A
β
peptides.
Candidate Gene Study
An association study performed on a particular gene(s) selected according to the
biology of the disease and/or their location within chromosome regions found to be
implicated in disease (by linkage or association study).
Full Genome Scan
A linkage or association analysis performed between the disease and polymorphic
markers that are spaced throughout the genome.
γ
-secretase
A multiprotein complex involved in intramembranous cleavage of APP-generating
C-terminal end of A
β
peptides. It contains four proteins: the catalytic component
(presenilins) and three cofactors (nicastrin, APH-1, and PEN-2).
Neurofbrillary Tangles (NFTs)
Abnormal intraneuronal deposits abundant in the brains of patients with AD and some
other neurodegenerative diseases. The main constituent of NFTs is
hyperphosphorylated tau protein.
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