Other Therapeutic Approaches
Books and Reviews
Tests for differences in allele or genotype frequencies between unrelated, affected, and
Autosomal Dominant Trait
A phenotype that is expressed in a heterozygote, which maps to a chromosome other
than the sex chromosomes.
Also known as BACE1; a transmembrane aspartyl protease involved in processing of
APP-generating N-terminal end of A
Candidate Gene Study
An association study performed on a particular gene(s) selected according to the
biology of the disease and/or their location within chromosome regions found to be
implicated in disease (by linkage or association study).
Full Genome Scan
A linkage or association analysis performed between the disease and polymorphic
markers that are spaced throughout the genome.
A multiprotein complex involved in intramembranous cleavage of APP-generating
C-terminal end of A
peptides. It contains four proteins: the catalytic component
(presenilins) and three cofactors (nicastrin, APH-1, and PEN-2).
Neurofbrillary Tangles (NFTs)
Abnormal intraneuronal deposits abundant in the brains of patients with AD and some
other neurodegenerative diseases. The main constituent of NFTs is
hyperphosphorylated tau protein.