179
Alzheimer’s Disease
Jun Wang, Silva Hecimovic and Alison Goate
Department of Psychiatry, Washington University School of Medicine,
St. Louis, MO, USA
1
Pathology and Epidemiology of Alzheimer’s Disease
182
2
The Genetics of Alzheimer’s Disease
184
2.1
The Genetics of Familial Alzheimer’s Disease
184
2.1.1
β
-amyloid Precursor Protein Mutations
184
2.1.2
Presenilin Mutations
185
2.2
The Genetics of Sporadic Alzheimer’s Disease
187
2.2.1
Apolipoprotein E
187
2.2.2
The Search for New Alzheimer’s Disease Susceptibility Genes
188
3
Molecular and Cellular Mechanisms Underlying Alzheimer’s Disease
189
3.1
β
-amyloid Precursor Protein
189
3.2
Production of A
β
–Proteolytic Processing of APP
189
3.3
β
-secretase – BACE1
190
3.4
γ
-secretase – Presenilins and Cofactors
191
3.4.1
Presenilins
191
3.4.2
Cofactors
192
3.5
Neuro±brillary Tangles and Tau Protein
193
3.6
Apolipoprotein E
194
4
Transgenic Mouse Models of Alzheimer’s Disease
195
4.1
APP Transgenic Mice
195
4.2
Presenilin 1/2 Transgenic Mice
196
4.3
Tau Transgenic Mice
197
4.4
Apolipoprotein E Transgenic Mice
198
4.5
Modulating and Enhancing the Phenotype: Transgenic Crosses
198
Encyclopedia of Molecular Cell Biology and Molecular Medicine, 2nd Edition
. Edited by Robert A. Meyers.
Copyright
2004 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
ISBN: 3-527-30543-2
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