Alternatively Spliced Genes
173
Modafferi, E.F., Black, D.L. (1997) A complex
intronic splicing enhancer from the c-src pre-
mRNA activates inclusion of a heterologous
exon,
Mol. Cell. Biol.
17
(11), 6537–6545.
Moore, M.J., Sharp, P.A. (1993) Evidence for two
active sites in the spliceosome provided by
stereochemistry of pre-mRNA splicing,
Nature
365
(6444), 364–368.
Nabholtz, J.M.,
Reese, D.M.,
Lindsay, M.A.,
Riva, A. (2002) HER2-positive breast cancer:
update on breast cancer international research
group trials,
Clin. Breast Cancer
3
(Suppl. 2),
S75–S79.
Nelson, K.K., Green, M.R. (1990) Mechanism for
cryptic splice site activation during pre-mRNA
splicing,
Proc. Natl. Acad. Sci. U.S.A.
87
(16),
6253–6257.
Nesic, D., Kramer, A. (2001) Domains in human
splicing factors SF3a60 and SF3a66 required
for binding to SF3a120, assembly of the 17S
U2 snRNP, and prespliceosome formation,
Mol. Cell. Biol.
(19), 6406–6417.
Nissim-Ra±nia, M.,
Krem, B.
(2002)
Splicing
regulation as a potential genetic modi±er,
Trends Genet.
18
, 123–127.
Nicoll, M.,
Akerib, C.C.,
Meyer, B.J.
(1997)
X-chromosome-counting
mechanisms
that
d
e
t
e
rm
in
en
em
a
t
od
es
e
x
,
Nature
388
(6638),
200–204.
Nguyen, V.N.,
Mirejovsky, T.,
Melinova, L.,
Mandys, V. (2000) CD44 and its v6 spliced
variant
in
lung
carcinomas:
relation
to
NCAM
,CEA
,EMAandUP1andprognos
t
ic
signi±cance,
Neoplasma
47
(6), 400–408.
Ono, Y., Ohno, M., Shimura, Y. (1994) Identi±-
cation of a putative RNA helicase (HRH1), a
human homolog of yeast Prp22,
Mol. Cell. Biol.
14
(11), 7611–7620.
Ono, R., Taki, T., Taketani, T., Kawaguchi, H.,
Taniwaki,
M.,
Okamura,
T.,
Kawa,
K.,
Hanada, R., Kobayashi, M., Hayashi, Y. (2002)
SEPTIN6, a human homologue to mouse
Septin6, is fused to MLL in infant acute
myeloid leukemia with complex chromosomal
abnormalities
involving
11q23
and
Xq24,
Cancer Res.
62
(2), 333–337.
Oshika,
Y.,
Nakamura,
M.,
Tokunaga,
T.,
Ohnishi, Y., Abe, Y., Tsuchida, T., Tomii, Y.,
Kijima, H.,
Yamazaki,
H.,
Ozeki,
Y.,
Tamaoki, N.,
Ueyama, Y.
(2000)
Ribozyme
approach to downregulate vascular endothelial
growth factor (VEGF) 189 expression in non-
smallcelllungcancer(NSCLC),
Eur. J. Cancer
36
(18), 2390–2396.
Pagani, F.,
Buratti, E.,
Stuani, C.,
Bendix, R.,
Dork, T., Baralle, F.E. (2002) A new type of
mutation causes a splicing defect in ATM,
Nat. Genet.
30
, 426–429.
Perez-Tur, J., Froelich, S., Prihar, G., Crook, R.,
Baker, M., Duff, K., Wragg, M., Bus±eld, F.,
Lendon, C.,
Clark, R.F.,
et al.
(1995)
A
mutation in Alzheimer’s disease destroying
a splice acceptor site in the presenilin-1 gene,
NeuroReport
7
, 297–301.
Petersen-Mahrt, S.K., Estmer, C., Ohrmalm, C.,
Matthews, D.A., Russell, W.C., Akusjarvi, G.
(1999) The splicing factor-associated protein,
p32, regulates RNA splicing by inhibiting
ASF/SF2 RNA binding and phosphorylation,
EMBO J.
18
(4), 1014–1024.
Pinto, A.L., Steitz, J.A. (1989) The mammalian
analogue
of
the
yeast
PRP8
splicing
protein
is
present
in
the
U4/5/6
small
nuclear ribonucleoprotein particle and the
spliceosome,
Proc
.Na
t
l
.Acad
.Sc
i
.U
.S
.A
.
86
,
8742–8746.
Ploos Van Amstel, J.K., Bergman, A.J., Van Beur-
den, E.A., Roijers, J.F., Peelen, T., Van Den
Berg, I.E.,
Poll-The, B.T.,
Kvittingen, E.A.,
Berger, R. (1996) Hereditary tyrosinemia type
1: novel missense, nonsense and splice con-
sensus mutations in the human fumarylace-
toacetate hydrolase gene; variability of the
genotype-phenotype relationship,
Hum. Genet.
97
(1), 51–59.
Poola, I.,
Speirs, V.
(2001)
Expression
of
alternatively spliced estrogen receptor alpha
mRNAs is increased in breast cancer tissues,
J. Steroid Biochem. Mol. Biol.
78
, 459–469.
Poltora, Z., Cohen, T., Neufeld, G. (2000) The
VEGF splice variants: properties, receptors,
and
usage
for
the
treatment
of
ischemic
diseases,
Herz
25
, 126–129.
Puig,
O.,
Gottschalk,
A.,
Fabrizio,
P.,
Seraphin, B.
(1999) Interaction
of
the
U1
snRNP with nonconserved intronic sequences
affects 5
0
splice site selection,
Genes Dev.
13
(5),
569–580.
Puttaraju,
M.,
Dipasquale,
J.,
Baker,
C.C.,
Mitchell,
L.G.,
Garcia-Blanco, M.A.
(2001)
Messenger RNA repair and restoration of
protein
function
by
spliceosome-mediated
RNA trans-splicing,
Mol. Ther.
4
(2), 105–114.
Query, C.C., Bentley, R.C., Keene, J.D. (1989) A
common RNA recognition motif identi±ed
within a de±ned U1 RNA binding domain of
the 70K U1 snRNP protein,
Cell
57
(1), 89–101.
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