154
Cytomegalovirus and Varicella–zoster Virus Vaccines
6.1
Single or Combined Vaccine Strategies in Human Clinical Trials
175
6.2
Animal Models Including Animal Homologues of Human CMV
and VZV
176
6.3
Quantitation of Immune Responses in Immunized Animals
and Humans
177
7
Concluding Remarks
178
Bibliography
179
Books and Reviews
179
Primary Literature
179
Keywords
Adjuvant
Natural or chemical substance that enhances antigen-stimulated antibody production
by B cells and/or activation of T cells.
Antigen
Foreign substance that can stimulate a speci±c immune response, usually speci±c
antibody; speci±c determinants on the antigen that are bound by the antibody are
known as epitopes.
Live Vaccine
Replication-competent viral or bacterial vaccine; either an attenuated form of a natural
infectious agent or a recombinant agent expressing a foreign gene.
Neutralizing Antibody
Antibody to the surface protein of virus particles that renders the virion noninfectious.
Seropositive versus Seronegative
Presence of antibody to a speci±c pathogen in the serum due to past infection or
immunization (seropositive) versus lack of antibody to a speci±c pathogen in the
serum because of no past infection or immunization.
Structural versus Nonstructural Protein
Viral protein species present in the virion (structural) versus viral protein species
synthesized in a virus-infected cell but not incorporated into the virion, such as viral
DNA polymerase of herpesviruses.
Subunit Vaccine
Puri±ed component of an infectious agent that is incapable of replication in the host
but can stimulate a protective immune response; for viruses, natural or
recombinant protein.
previous page 1474 Encyclopedia of Molecular Cell Biology and Molecular Medicine read online next page 1476 Encyclopedia of Molecular Cell Biology and Molecular Medicine read online Home Toggle text on/off