153
Cytomegalovirus and
Varicella–zoster Virus Vaccines
Lawrence A. Hunt
University of Louisville School of Medicine, Louisville, KY, USA
1
Introduction to Human Cytomegalovirus and Varicella-zoster Virus
155
1.1
Human Diseases from Primary and Recurrent Infection
155
1.2
Naturally Acquired Protective Immunity
157
1.3
EfFcacy
of Live-attenuated Varicella Vaccine in Preventing Chickenpox
157
1.4
Vaccine Strategies to Prevent Congenital CMV and Disease in
Immunocompromised Adults
159
1.5
Vaccine Strategies to Prevent Zoster in the Elderly and
Immunocompromised Adults
159
2
Virion Structure and Composition
160
2.1
Viral DNA Genomes and SpeciFc Gene Sequences for
Recombinant Vaccines
160
2.2
Immunogenic Proteins for Eliciting Neutralizing Antibody
161
2.3
Immunogenic Proteins for Stimulating Cytotoxic T cells
164
3
Protein Subunit Vaccines
165
3.1
Natural and Recombinant CMV gB Protein
165
3.2
Other Recombinant and Chimeric CMV Proteins
168
3.3
Recombinant VZV gE, gB, Tegument, and Chimeric Proteins
168
4
Live-recombinant Virus Vaccines
169
4.1
Recombinant Poxviruses Expressing CMV or VZV Genes
169
4.2
Recombinant Adenoviruses Expressing CMV Genes
172
4.3
Recombinant VZV Expressing Heterologous Viral Genes
173
5
Plasmid DNA Vaccines for VZV and CMV
173
6
Clinical Testing of New Vaccines
175
Encyclopedia of Molecular Cell Biology and Molecular Medicine, 2nd Edition
. Edited by Robert A. Meyers.
Copyright
2004 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
ISBN: 3-527-30545-9
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