124
Cytokines: Interleukins
Tab. 2
Molecular characteristics of human interleukins and their receptors.
Interleukin
Precursor,
no. of AA
Mature
protein,
no. of AA.
Glycosylation
DisulFde
bonds
Monomer
(M) or dimer
(D)
Chromosome
assignment
of gene and
organization
(exon/intron)
Receptors
IL-1
α
271
159
0
M
2 (7/6)
80 kDa type I receptor
IL-1ß
269
153
1
M
2 (7/6)
68 kDa type II receptor
IL-1ra
177
152
N-linked
M
2
IL-2
153
133
O-linked
1
M
4 (4/3)
55 kDa
α
-chain
75 kDa ß-chain
65 kDa
γ
-chain
IL-3
152
133
N-linked
1
M
5 (5/4)
80 kDa
α
-chain
120 kDa ß-chain
IL-4
154
129
N-linked
3
M
5 (4/3)
130 kDa binding protein; other
component?
IL-5
134
114
N-linked
1
D
5 (4/3)
80 kDa
α
-chain
120 kDa ß-chain
IL-6
212
184
N-linked
2
M
7 (5/4)
80 kDa
α
-chain
130 kDa ß-chain - (gp130)
IL-7
177
152
N-linked
3
M
8
68 kDa binding protein
IL-8
99
72
2
D
4 (c-x-c)
17 (c-c) (4/3)
58 kDa binding proteins; two
types at least
IL-9
144
126
N-linked
5
M
5 (5/4)
64 kDa binding protein
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