120
Cytokines: Interleukins
Tab. 1
Interleukins and former nomenclature.
Interleukin
Former names
Interleukin-1
α
(IL-1
α
)
Endogenous pyrogen (EP); lymphocyte activating factor (LAF);
hemopoietin-1 (HP-1)
Interleukin-1ß (IL-1ß)
As for IL-1
α
; osteoclast-activating factor (OAF)
Interleukin-1 receptor
antagonist (IL-1ra)
Interleukin-2 (IL-2)
T-cell growth factor-1 (TCGF-1); killer helper factor (KHF)
Interleukin-3 (IL-3)
Multiple colony stimulating factor (multi-CSF); hemopoietic cell growth
factor (HCGF)
Interleukin-4 (IL-4)
B-cell stimulating factor-I (BSF-I); T-cell growth factor-II (TCGF-II);
macrophage activation factor (MAF)
Interleukin-5 (IL-5)
T-cell replacing factor-I (TRF-I); eosinophil differentiation factor (EDF);
IgA-enhancing factor
Interleukin-6 (IL-6)
B-cell stimulating factor-2 (BSF-2); hybridoma-plastocytoma growth factor
(HPGF); hepatocyte stimulating factor (HSF)
Interleukin-7 (IL-7)
Lymphopoietin-1 (LP-1); thymocyte growth factor (THGF); pre-B-cell
growth factor (PBGF)
Interleukin-8 (IL-8)
a
Macrophage-derived neutrophil chemotactic factor (MDNCF); neutrophil
activating factor-1 (NAF-1)
Interleukin-9 (IL-9)
T-cell growth factor-III (TCGF-III); p40; mast-cell enhancing activity
Interleukin-10 (IL-10)
Cytokine synthesis inhibitory factor (CSIF)
Interleukin-11 (IL-11)
Adipogenesis inhibitory factor (AGIF)
Interleukin-12 (IL-12)
Natural killer stimulatory factor (NKSF); cytotoxic lymphocyte maturation
factor (CLMF)
Interleukin-13 (IL-13)
P-600
Interleukin-14 (IL-14)
High molecular weight B-cell growth factor (HMW-BCGF)
Interleukin-15 (IL-15)
Interleukin-16 (IL-16)
Lymphocyte chemoattractant factor (LCF)
Interleukin-18 (IL-18)
Interferon gamma inducing factor
Interleukin-22 (IL-22)
IL-10-related T-cell-derived inducible factor (IL-TIF)
Interleukin-24 (IL-24)
Melanoma differentiation antigen-7 (MDA-7)
Interleukin-26 (IL-26)
AK155
a
IL-8 is a member of the small cytokine or chemokine superfamily. There are two main subgroups
distinguished on the basis of the positions of cysteine residues. IL-8 is a member of the CXC Ligand
(CXCL) subgroup, which also includes platelet factor 4 (PF4), ß-thromboglobulin (ß-TG), gro-
α
,
gro-ß, IP-10, and so on. The CC Ligand (CCL) subgroup includes monocyte chemoattractant
protein-1 (MCP-1), RANTES, macrophage inflammatory proteins (MIP-1
α
MIP-1ß), I-309, and so on.
and their expression may also change ac-
cording to the stage of cell development or
differentiation.
Overall, the regulation of cellular re-
sponses by interleukins is complex, and
probably even more so where they act as
mixtures of interleukins or with other cy-
tokines or other noncytokine mediators.
The complex interaction of interleukins
and other mediators, which is envisaged
to occur
in vivo
, has often obscured the
physiological roles of interleukins. How-
ever, do they have any major physiological
roles or do they have one or more acces-
sory or subordinate roles? The fact that
most interleukins are inducibly, rather
previous page 1440 Encyclopedia of Molecular Cell Biology and Molecular Medicine read online next page 1442 Encyclopedia of Molecular Cell Biology and Molecular Medicine read online Home Toggle text on/off