75
Combinatorial Phage Antibody
Libraries
Michael B. Zwick, R. Anthony Williamson, and Dennis R. Burton
The Scripps Research Institute, La Jolla, CA, USA
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Combinatorial Antibody Libraries
77
2.1
The Early Libraries: The Lambda Phage System
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2.2
Constructing Antibody Libraries on the Surface of a Phage
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3
Selection from Antibody Phage Libraries
84
4
Applications of Combinatorial Antibody Libraries
85
4.1
Antibodies from Immune Donors
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4.1.1
Antibodies against Viruses and Prions
88
4.1.2
Antibodies against Tumor-associated Antigens
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4.1.3
Intracellular Antibodies or ‘‘Intrabodies’’
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4.2
Antibodies in the Absence of Immunization
93
4.2.1
Naive Libraries
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4.2.2
Semisynthetic Libraries
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5
Summary
95
Bibliography
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Books and Reviews
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Primary Literature
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Keywords
Antibody Repertoire
The array of different antibody molecules that may be synthesized by the
immune system.
Encyclopedia of Molecular Cell Biology and Molecular Medicine, 2nd Edition
. Edited by Robert A. Meyers.
Copyright
2004 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
ISBN: 3-527-30545-9
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