1
Chromosome Organization
within the Nucleus
Wallace F. Marshall
Dept. of Molecular, Cellular, and Developmental Biology Yale University,
New Haven, CT 06520
1
Introduction
3
2
Chromosome Positioning
3
2.1
Analysis of Polytene Chromosomes
3
2.2
Fluorescence
In Situ
Hybridization (FISH)
4
2.3
Interactions with the Nuclear Envelope
4
2.4
Retention of Mitotic Chromosome Geometry
5
3
Molecular Interactions That Specify Nuclear Architecture
6
3.1
Nuclear Lamins
6
3.2
Nuclear Pores
6
3.3
Nuclear Matrix
6
4
Interphase Chromatin Movement
7
4.1
Evidence for Chromatin Immobilization
7
4.2
Evidence for Chromatin Diffusion
7
4.3
Evidence for Active Chromatin Movement
8
5
Regulation of Gene Expression by Nuclear Architecture
8
5.1
Role of Nuclear Envelope Interactions in Gene Silencing
8
5.2
Gene Gating
8
5.3
Nuclear Compartmentalization and Gene Expression
9
6
Role of Nuclear Architecture in Chromosome Interactions
9
6.1
Regulation of Interactions by Constrained Diffusion
9
6.2
Robertsonian Translocations
10
6.3
Chromosome Rearrangements in Cancer
10
Encyclopedia of Molecular Cell Biology and Molecular Medicine, 2nd Edition
. Edited by Robert A. Meyers.
Copyright
2004 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
ISBN: 3-527-30545-9
previous page 1321 Encyclopedia of Molecular Cell Biology and Molecular Medicine read online next page 1323 Encyclopedia of Molecular Cell Biology and Molecular Medicine read online Home Toggle text on/off