Alternatively Spliced Genes
129
5
splice sites
Branch sites
Human U2 introns
Human U2 introns
Yeast U2 introns
Yeast U2 introns
U12 introns
3
splice sites
positions:
Human U2 introns
Yeast U2 introns
U12 introns
U12 introns
positions:
positions:
3
9
12
11
10
9
8
7
6
5
4
3
2
11 2 3
8
7
6
5
4
3
2
1123456
2
1
1
2
3
4
5
6
7
8
9 10 11 12
Fig. 2
Thesequencefeaturesatthe5
0
splice site, branch site,
and 3
0
splice site as derived from representative sets of
introns of corresponding types. (ModiFed with permission
from Burge, C.B., Tuschl, T.H., Sharp, P.A. (1999). in: The
RNA World, Gesteland, R.±., Cech, T.R., Atkins, J.±. (Eds)
The
RNA World
, Cold Spring Harbor Laboratory Press, New York,
pp. 525–560). The frequency of each nucleotide (A, G, T, or C)
at each sequence position is depicted by the heights of the
corresponding letters in the diagram.
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