125
Alternatively Spliced Genes
Jane Y. Wu
1
,
2
,L
iyaYuan
1
, and Necat Havlioglu
1
1
Washington University School of Medicine, St. Louis, MO, USA
2
Departments of Pediatrics, Cell and Developmental Biology and Pharmacology;
John F. Kennedy Vanderbilt University Medical Center, Nashville, TN USA
1
Pre-mRNA Splicing and Splicing Machinery
127
1.1
Splicing Machinery: Spliceosome
127
1.2
Splicing Signals
128
1.3
Spliceosomal UsnRNP Biogenesis
137
1.4
Spliceosome Assembly
138
1.5
Biochemical Mechanisms of pre-mRNA Splicing
141
2
Alternative pre-mRNA Splicing
142
2.1
Alternative Splicing and its Role in Regulating Gene Activities
and Generating Genetic Diversity
142
2.1.1
Different Patterns of Alternative Splicing
143
2.1.2
Alternative Splicing and Genetic Diversity
143
2.2
Mechanisms Underlying Alternative Splicing Regulation
144
2.2.1
Splicing Signals and Splicing Regulatory Elements
145
2.2.2
Trans-acting Splicing Regulators
148
2.3
Tissue-speciFc and Developmentally Regulated Alternative Splicing
151
2.4
Regulation of Alternative Splicing in Response to Extracellular Stimuli
152
3
Pre-mRNA Splicing and Human Diseases
152
3.1
Splicing Defects in Human Diseases
153
3.2
Molecular Mechanisms Underlying Splicing Defects Associated
with Disease
157
4
Perspectives on Diagnosis and Treatment of Diseases Caused by
pre-mRNA Splicing Defects
160
4.1
Diagnosis of Human Diseases Caused by Splicing Defects
160
Encyclopedia of Molecular Cell Biology and Molecular Medicine, 2nd Edition
. Edited by Robert A. Meyers.
Copyright
2004 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
ISBN: 3-527-30543-2
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