580
Chirality in Biology
Bibliography
615
Books and Reviews
615
Primary Literature
615
Keywords
Chiral
Describing an object or a molecule whose image in a plane mirror cannot be
superposed on the original.
Chiral Drug
A pharmaceutical agent that exists in two enantiomeric forms. In many cases, the two
forms will have different physiological activity.
Chiral Methyl
A methyl group with the three hydrogen isotopes,
1
H,
2
H,
3
H. When combined with
another group, R, a chiral molecule is obtained: R-C
1
H
2
H
3
H.
Chiral Phosphorous Atom
A phosphorous atom linked to the three oxygen isotopes,
16
O,
17
O,
18
O, and to another
group, usually OR: hence, RO–P–
16
O
17
O
18
O.
Chiral Recognition
Discrimination between enantiomers achieved by enzymes or biological receptor
molecules and by some chemical catalysts and reagents.
Confguration
Three-dimensional arrangement of atoms or groups of atoms at an element of
chirality; arrangements resulting from rotation about single bonds are excluded.
Diastereoisomer
Stereoisomers not in an object-/mirror-image relationship.
D/L Notation
An arbitrary convention to denote conFguration about a chiral element in
α
-amino
acids, some
α
-hydroxy acids, and carbohydrates.
Enantiomer
Stereoisomers that are in an object-/mirror-image relationship.
Homochiral
Amoleculeorassemblyofmoleculesinwhichthecomponentshavelikechirality
sense. Normal protein amino acids have L-conFguration; for naturally occurring
carbohydrates, the D-conFguration predominates. The antonym is heterochiral.
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