Chicken Genome
547
matches to 90% of the human disease
genes in the ‘‘morbid map’’ – a subset
of human genes linked to known hered-
itary diseases. The EST resource is likely
to contain additional chicken genes with,
as yet, no known orthologs, or perhaps
even genes that are avian speciFc. Ten
thousand cDNAs from EST collections
are currently being sequenced. These EST
resources provide exciting opportunities
for gene expression studies and for de-
vising new tests for gene function using
chick embryos.
8
Perspectives
During the past decade, the progress in
chicken genomics has beneFted from the
sharing of data. ChickNET (http://dev.
chicken-genome.org/) is one organization
that tries to encourage this ethic. Us-
ing common resources, such as genetic
mapping populations, genetic markers,
physical probes, BAC libraries, cDNA and
EST resources, RH mapping panels, mi-
croarrays, and the genome sequence, it
will be possible to obtain different views of
the chicken genome. A wealth of genome
data for the chicken has already been pro-
duced using these resources and tools, and
this will continue in the future. A num-
ber of genome mapping databases have
been produced to store and manage such
data. These databases include structural
information, such as genetic maps, cyto-
genetic maps and banded karyotypes, RH
maps, BAC and other clone-based maps,
and the gene models based on EST se-
quences and other predictive tools. In
addition, there will be the need to inte-
grate more functional information, such
as expression data (ESTs,
in situ
hybridiza-
tion, etc.), mapping of genetic mutations,
complex traits (QTL, Quantitative Trait
Loci mapping) and phenotype using other
tools (e.g.
RNAi
). ±inally, such a genome
view of the chicken needs to be com-
pared and integrated with the views on
other genomes, such as human, Fsh, and
so on.
See also
Genetics, Molecular Basis
of;
Genomic
Sequencing
(Core
Article).
Bibliography
Books and Reviews
Bitgood, J.J., Somes, R.G. Jr. (1993) Gene Map of
the Chicken (
Gallus gallus
or
G. domesticus
), in:
O’Brien, S.J. (Ed.)
Genetic Maps
, 6th edition,
Cold Spring Harbour Laboratory Press, Cold
Spring Harbour, pp. 4332–4342.
Boardman,
P.E.,
Sanz-Ezquerro,
J.,
Over-
ton, I.M., Burt, D.W., Bosch, E., ±ong, W.T.,
Tickle, C., Brown, W.R., Wilson, S.A., Hub-
bard, S.J. (2002) A comprehensive collection
of chicken cDNAs,
Curr. Biol.
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Burt, D.W. (2003) Comparative Genomics, in:
Muir, W.M., Aggrey, S.E. (Eds.)
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