AIDS/HIV, Molecular and Cell Biology
121
the RNA polymerase II C-terminal domain,
Nucleic Acids Res.
24
, 501–508.
Ho,
D.D.,
Neumann,
A.U.,
Perelson,
A.S., Chen, W., Leonard, J.M., Markowitz, M.
(1995) Rapid turnover of plasma virions and
CD4 lymphocytes in HIV-1 infection,
Nature
373
, 123–126.
Huang, Y., Paxton, W.A., Wolinsky, S.M., Neu-
mann, A.U.,
Zhang, L.,
He, T.,
Kang, S.,
Ceradini, D., Jin, Z., Yazdanbakhsh, K., Kun-
stman, K.,
Erickson, D.,
Dragon, E.,
Lan-
dau, N.R.,
Phair, J.,
Ho, D.D.,
Koup, R.A.
(1996) The role of a mutant CCR5 allele in
HIV-1 transmission and disease progression,
Nat. Med.
2
, 1240–1243.
Isel, C., Karn, J. (1999) Direct evidence that
HIV-1 Tat stimulates RNA polymerase II
carboxyl-terminal domain hyperphosphoryla-
tion during transcriptional elongation,
J. Mol.
Biol.
290
, 929–941.
Jacks, T.,
Power, M.D.,
Masiarz, F.R.,
Lu-
ciw, P.A.,
Barr, P.J.,
Varmus, H.E.
(1988)
Characterization of ribosomal frameshifting
in HIV-1 gag-pol expression,
Nature
331
,
280–283.
Jost, S.,
Bernard, M.C.,
Kaiser, L.,
Yerly, S.,
Hirschel, B., Samri, A., Autran, B., Goh, L.E.,
Perrin, L.
(2002)
A
patient
with
HIV-1
superinfection,
N. Engl. J. Med.
347
, 731–736.
Jowett, J.B., Planelles, V., Poon, B., Shah, N.P.,
Chen, M.L., Chen, I.S. (1995) The human
immunode±ciency virus type 1 vpr gene
arrests infected T cells in the G2
+
Mphaseof
the cell cycle,
J. Virol.
69
, 6304–6313.
Kestler,
H.W.
III,
Ringler,
D.J.,
Mori, K.,
Panicali, D.L., Sehgal, P.K., Daniel, M.D.,
Desrosiers, R.C. (1991) Importance of the nef
gene for maintenance of high virus loads and
for development of AIDS,
Cell
65
, 651–662.
Kino, T., Gragerov, A., Slobodskaya, O., Tsopa-
nomichalou, M., Chrousos, G.P., Pavlakis,
G.N. (2002) Human immunode±ciency virus
type 1 (HIV-1) accessory protein Vpr induces
transcription of the HIV-1 and glucocorticoid-
responsive promoters by binding directly
to
p300/CBP
coactivators,
J.
Virol.
76
,
9724–9734.
Kirchhoff, F., Greenough, T.C., Brettler, D.B.,
Sullivan, J.L., Desrosiers, R.C. (1995) Brief
report: absence of intact nef sequences in a
long-term survivor with nonprogressive HIV-1
infection,
N. Engl. J. Med.
332
, 228–232.
Kjems, J., Calnan, B.J., Frankel, A.D., Sharp, P.A.
(1992) Speci±c binding of a basic peptide from
HIV-1 Rev,
EMBO J.
11
, 1119–1129.
Koup, R.A., Safrit, J.T., Cao, Y., Andrews, C.A.,
McLeod, G.,
Borkowsky, W.,
Farthing, C.,
Ho, D.D.
(1994)
Temporal
association
of
cellular immune responses with the initial
control
of
viremia
in
primary
human
immunode±ciency virus type 1 syndrome,
J.
Virol.
68
, 4650–4655.
Le Gall, S., Erdtmann, L., Benichou, S., Berlioz-
Torrent, C., Liu, L., Benarous, R., Heard, J.M.,
Schwartz, O. (1998) Nef interacts with the mu
subunit of clathrin adaptor complexes and
reveals a cryptic sorting signal in MHC I
molecules,
Immunity
8
, 483–495.
Le
Rouzic, E.,
Mousnier, A.,
Rustum, C.,
Stutz, F., Hallberg, E., Dargemont, C., Beni-
chou, S. (2002) Docking of HIV-1 Vpr to the
nuclear envelope is mediated by the interac-
tion with the nucleoporin hCG1,
J. Biol. Chem.
277
, 45091–45098.
Lever, A.,
Gottlinger, H.,
Haseltine, W.,
So-
droski, J. (1989) Identi±cation of a sequence
required for ef±cient packaging of human im-
munode±ciency virus type 1 RNA into virions,
J. Virol.
63
, 4085–4087.
L
i
u
,R
.
,P
a
x
t
o
n
,W
.
A
.
,C
h
o
e
,S
.
,C
e
r
a
d
i
n
i
,D
.
,
Martin, S.R.,
Horuk, R.,
MacDonald, M.E.,
Stuhlmann, H.,
Koup, R.A.,
Landau, N.R.
(1996)
Homozygous
defect
in
HIV-1
coreceptor
accounts
for
resistance
of
some multiply-exposed individuals to HIV-1
infection,
Cell
86
, 367–377.
Lyall, E.G., Blott, M., de Ruiter, A., Hawkins, D.,
Mercy,
D.,
Mitchla,
Z.,
Newell,
M.L.,
O’Shea, S.,
Smith,
J.R.,
Sunderland,
J.,
Webb, R., Taylor, G.P. (2001) Guidelines for
the management of HIV infection in pregnant
women and the prevention of mother-to-child
transmission,
HIV Med.
2
, 314–334.
Lyles,
R.H.,
Munoz,
A.,
Yamashita,
T.E.,
Bazmi, H.,
Detels, R.,
Rinaldo, C.R.,
Mar-
golick, J.B., Phair, J.P., Mellors, J.W., Multi-
center AIDS Cohort Study. (2000) Natural
history of human immunode±ciency virus
type 1 viremia after seroconversion and proxi-
mal to AIDS in a large cohort of homosexual
men,
J. Infect. Dis.
181
, 872–880.
M
a
l
im
,M
.H
.
,H
a
u
b
e
r
,J
.
,L
e
,S
.
Y
.
,M
a
i
z
e
l
,
J.V., Cullen, B.R. (1989) The HIV-1 rev
trans-activator
acts
through
a
structured
target sequence to activate nuclear export
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