Chaperones, Molecular
517
particularly in the whole area of ‘‘qual-
ity control’’ – the optimization of protein
folding activity under both normal and
stressed conditions, and the rapid dis-
posal of proteins which fail to meet the
cell’s requirements. Attention is also shift-
ing to examining the roles of different
chaperones in disease, most notably the
protein-folding diseases such as the prion
diseases, Alzheimer’s, Parkinson’s, and
others. The possibility that a more com-
plete understanding of the ways in which
chaperones are involved in such diseases
may lead to new therapies is an exciting
one and a powerful incentive to further
research in this Feld.
Acknowledgments
I am grateful to Professor R John Ellis,
±RS, for his many useful comments on an
earlier draft of this article.
See
also
Circular Dichroism in
Protein Analysis.
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