378
Cell Nucleus Biogenesis, Structure and Function
3.5
Nuclear Architecture and Nuclear Compartments
400
3.5.1
Nuclear Compartments
400
3.5.2
The Nucleolus
401
3.5.3
Nuclear Bodies and Domains
402
3.5.4
Nuclear Speckles
403
3.5.5
Active Sites – Synthetic Factories
404
3.6
Chromosome Territories
408
3.6.1
Chromosome Structure
410
3.6.2
Functional Implications of Chromosome Structure and Location
410
3.7
The Principles of Global Nuclear Structure
411
3.7.1
Organizing the Cytoplasm
411
3.7.2
The Nuclear Matrix – Fact or Fiction
413
3.7.3
Proteins of the Nuclear Matrix
413
3.7.4
Functions at the Matrix
415
4
Integrating Nuclear Structure and Function
415
4.1
Chromatin Structure and Function
416
4.1.1
Chromatin Function
416
4.1.2
DNA Packaging and Chromatin
416
4.1.3
Euchromatin and Heterochromatin
418
4.1.4
Histone Modi±cations
418
4.1.5
ATP-dependent Chromatin Remodeling Machines
419
4.2
Higher-order Chromatin Folding
420
4.2.1
Chromatin Domains and Loops
421
5
Overview
423
Bibliography
423
General Reference and Books
423
Research Articles are Reviews
424
Keywords
Chromosome
The structural unit of genetic material.
Nuclear Architecture
Nuclear structures that influence nuclear function.
Nuclear Matrix
Protein network throughout the nucleus.
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