377
Cell Nucleus Biogenesis,
Structure and Function
Dean A. Jackson
Department of Biomolecular Sciences, Manchester, UK
1
Introduction
379
2
Nuclear Function
380
2.1
Gene Expression
381
2.1.1
Activating Gene Expression
381
2.1.2
Specifc Transcription Factors
382
2.1.3
Posttranscriptional Events – RNA Processing
383
2.2
DNA Replication
384
2.2.1
DNA Repair
386
2.3
The Cell Division Cycle
388
2.3.1
Mitosis
389
2.3.2
Meiosis
391
3
Nuclear Structure
392
3.1
Nuclear Pore Structure
392
3.1.1
Pore Function
393
3.2
The Nuclear Lamina
393
3.2.1
The Lamin Genes
395
3.2.2
The Lamin Proteins and Filament Assembly
395
3.2.3
Lamin Function
395
3.2.4
Lamin-associated Proteins
396
3.2.5
Lamin Mutants
396
3.3
Biogenesis o± the Nuclear Envelope During Cell Proli±eration
397
3.4
Nuclear Transport and Karyopherins
398
3.4.1
The RanGTP/GDP Cycle
398
3.4.2
RNA Export Pathways
399
3.4.3
Nuclear Transport – Facilitated Di±±usion
400
Encyclopedia of Molecular Cell Biology and Molecular Medicine, 2nd Edition
. Edited by Robert A. Meyers.
Copyright
2004 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
ISBN: 3-527-30544-0
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