104
AIDS/HIV, Molecular and Cell Biology
I
Reverse
transcription
Coreceptor
binding & fusion
Entry &
uncoating
Nuclear
translocation
of PIC
Integration
Rev
independent
transport
Rev dependent
transport
Transcription
Translation at
polysome
Receptor
binding
Translation
at RER
Immature
particle
Marture
virion
Membrane targeting
Capsid assembly
& budding
GAG binding
Ψ
Ψ
Ψ
Ψ
Ψ
Ψ
Ψ
Ψ
Ψ
Ψ
Fig. 4
Retroviral life cycle.
reverse transcription process are that both
the RNA genomes are used as a template
to produce a DNA copy in which template
switching can occur such that the resultant
DNA may be a combination of copies of
segments from each of the RNA strands.
Secondly, the resulting double-stranded
DNA terminal sequences have both been
templated by the 3
0
long terminal repeat.
It is during this reverse transcription step
that the combination of template switch-
ing and nucleotide misincorporation, due
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